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* Correspondence: Marco de Scordilli, [email protected] These authors have contributed equally to this work and share first authorship Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

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Glycine, an important one-carbon source, is the third amino acid added to -glutamylcysteine, the condensation product of glutamate and cysteine, to form glutathione (Figure 1)